Effect of gliprolines on lipid peroxidation rate in male rats’ immunocompetent organs under conditions of information stress

Introduction. The study of various aspects the stress-reactivity body’s immune system, along with search for correction tools characterized by immunoregulatory properties, is one most relevant areas physiology and pharmacology. Currently, neuropeptides belonging to group glурrоlins (the registered drug “sеlаnk” new compounds Рro-Glу-Рro-Leu Рro-Glу-Рro) are particular interest in practical application as promising bioregulators, their effects on processes free radical oxidation, well ability restore changes from including those formed response stress. aim : was effect intensity lipid peroxidation, catalase activity spleen thymus male rats under experimental information Material methods . performed white nonlinear which model stress, based formation behavior animals a multi-alternative food-producing maze, reproduced 20 days. initial content malondialdehyde, rate spontaneous ascorbate-dependent peroxidation were determined standard spectrophotometric methods, homogenate evaluated. Results Under studied stress conditions, an increase noted. Against background introduction sеlаnk, Рro-Glу-Рro Рro-Glу-Рro-Leu, suppression homogenates tissue established (a decrease level, peroxidation). Conclusions Injection glyprolins (sеlаnk, informational conditions contributes processes, indicates stress-protective immunocorrective substances.